CHLORHEXIDINE BASE

CHLORHEXIDINE BASE

PRODUCT IDENTIFICATION

CAS NO

55-56-1

CHLORHEXIDINE

EINECS NO. 200-238-7

FORMULA [(CH₂)₃NHC(=NH)NHC(=NH)NHC₆H₄Cl]₂

MOL WT. 505.46

H.S. CODE

TOXICITY

Oral rat LD50: 9200ul/kg

SYNONYMS Clorhexidina Base;

Bis(5-(p-chlorophenyl)biguanidinio)hexane; Hexamethylenebis(5-(4-chloro phenyl)biguanide); N,N''-bis(4-chlorophenyl)-3,12- diimino-Tetraaza tetradecanediimidamide; 1, 6-Di-(4-chloro phenyl diguanido ) hexane; 1,1'-Hexamethylenebis [5-(4- chlorophenyl) biguanide];

SMILES

Sodium Dicyanamide, Hexamethylene-biscyanoguanidine

CLASSIFICATION

DISINFECTANTS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

White to pale yellow powder, odorless

MELTING POINT

132 - 136 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

slightly

pH 5 - 8

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Chlorhexidine is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms, facultative anaerobes, aerobes, and yeast. Chlorhexidine is used as an ingredient of bacteriostatic and bacteriocidal by the activity of membrane disruption in a general purpose skin general skin cleansers, surgical scrub, germicidal hand rinses and animal disinfection products. It is used as a topical antiinfective for mucous membranes and as a preservative for eye drops. Chlorhexidine is also used as an antiseptic ingredient used in mouthwash to prevent oral plaque, oral bacteria and in treating gingivitis. Its salts for commercial uses include:

Chlorhexidine salt	CAS RN
Chlorhexidine diacetate	56-95-1
Chlorhexidine dihydrochloride	3697-42-5
Chlorhexidine digluconate	18472-51-0
Chlorhexidine phosphanilate	77146-42-0

In addition to antibacterial activity, chlorhexidine phosphanilate is also used as a spermatocidal agent.

Active ingredients in mouthwash or dental caries prophylactic include;

Ingredient	CAS RN
Amosan	8059-88-9
Benzalkonium chloride	8001-54-5
Cetylpyridinium chloride	123-03-5
Chlorhexidine gluconate	18472-51-0
Chlorhexidine	55-56-1
Dectaflur	36505-83-6
Eucalyptol	470-82-6
Hetaflur	3151-59-5
Hydrogen peroxide	7722-84-1
Ipexidine mesylate	69017-90-9
Listerine	51273-66-6
Meridol	120812-75-1
Metesculetol	52814-39-8
Methyl salicylate	119-36-8
Olaflur	6818-37-7
Rhatany	84775-95-1
Salifluor	78417-90-0
Sanguinarine	2447-54-3
Sodium monofluorophosphate	10163-15-2
Sodium fluoride	7681-49-4
Stannous fluoride	7783-47-3
Thymol	89-83-8
Tiodonium chloride	38070-41-6
Zinc chloride	7646-85-7
Zinc fluoride	7783-49-5

SALES SPECIFICATION

APPEARANCE

white powder

IDENTITY

Complies (IR Spectrum)

CONTENT

98.0 - 102.0% (HPLC)

MELTING POINT

132 - 136 C

RESIDUE ON IGNITION

0.1% max

COLOR

0.03 max at 480 nm (20% Chlorhexidine Gluconate)

p-CHLORO ANILINE

200ppm max

TRANSPORTATION

PACKING

25kgs in Drum

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: n/a, Risk Phrases: 36/37/38, Safety Phrases: 28/38/7

GENERAL DESCRIPTION OF ANTISEPTIC AGENT

Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. It is essentially nontoxic to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate.
Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form.
Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective.
Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide.
Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums.
Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde.
Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose.
Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems.
Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.

PRICE